BTB and CNC homology 1 (Bach1) induces lung cancer stem cell phenotypes by stimulating CD44 expression.

doi:10.1186/s12931-021-01918-2

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Article

BTB and CNC homology 1 (Bach1) induces lung cancer stem cell phenotypes by stimulating CD44 expression.

Respiratory research - 23 Dec 2021

Jiang Pan, Li Fan, Liu Zilong, Hao Shengyu, Gao Jian, Li Shanqun

Abstract excerpt

BACKGROUND: Growing evidence suggests that cancer stem cells (CSCs) are responsible for cancer initiation in tumors. Bach1 has been identified to contribute to several tumor progression, including lung cancer. The role of Bach1 in CSCs remains poorly known. Therefore, the function of Bach1 on lung CSCs was focused currently. METHODS: The expression of Bach1, CD133, CD44, Sox2, Nanog and Oct4 mRNA was assessed...

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PMID: 34949193
DOI: 10.1186/s12931-021-01918-2
PMCID: PMC8697453

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