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Article

Melioidosis of the Central Nervous System: Impact of the bimA Bm Allele on Patient Presentation and Outcome

4 Feb 2022

Abstract excerpt

BACKGROUND: The autotransporter protein Burkholderia intracellular motility A (BimA) facilitates the entry of Burkholderia pseudomallei into the central nervous system (CNS) in mouse models of melioidosis. Its role in the pathogenesis of human cases of CNS melioidosis is incompletely defined. METHODS: Consecutive culture-confirmed cases of melioidosis at two sites in tropical Australia after 1989 were reviewed....

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PMID: 35137005
DOI: 10.1093/cid/ciac111

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Related research

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Research trail→

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Melioidosis of the Central Nervous System: Impact of the bimA Bm Allele on Patient Presentation and OutcomePMID 35137005Read ↗

Clinical Burkholderia pseudomallei isolates from north Queensland carry diverse bimABm genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strainsSemantic proximity Read ↗

Clinical <i>Burkholderia pseudomallei</i> isolates from Queensland carry diverse <i>bimA<sub>Bm</sub></i> genes that are associated with central nervous system disease and are phylogenomically distinct from other Australian strainsSemantic proximity Read ↗

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Burkholderia pseudomallei BimC Is Required for Actin-Based Motility, Intracellular Survival, and VirulenceSemantic proximity Read ↗

Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis.Semantic proximity Read ↗

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