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Article

Genetic evidence elucidates the mediating role of sex hormone-binding globulin in the causal relationship linking insomnia to carpal tunnel syndrome.

Human genomics - 16 Jun 2026

Huang Junming, Chen Mingxing, Zhou Song, Liu Jun, Li Jiangxi, Huang Shanhu, Zou Zhiyuan, Deng Kui

Abstract excerpt

BACKGROUND: Carpal tunnel syndrome (CTS) is the most prevalent type of entrapment neuropathy and is frequently associated with sleep disturbances. However, the directionality of this association remains ambiguous, necessitating an exploration of potential mediators. Sex hormone-binding globulin (SHBG) may affect the risk of CTS by modulating the sex hormone milieu within the carpal tunnel. This study seeks to...

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Share to SHBG gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 42304454
DOI: 10.1186/s40246-026-01006-w
PMCID: PMC13505084

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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