Glucose Levels and Granulocyte Colony-Stimulating Factor May Partially Mediate the Association Between Genetic Liability to Diabetes and Carpal Tunnel Syndrome.

Abstract excerpt

BACKGROUND: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, imposing substantial clinical and socioeconomic burdens due to chronic pain, functional disability, and reduced quality of life. While diabetes is a well-established risk factor for CTS in observational studies, the causal nature of this association and the mediating roles of glucose levels and inflammatory pathways remain unclear....

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