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Article

Causal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry.

Frontiers in endocrinology - 1 Jan 2024

Duan Xiping, Zhang Tianchi, Wang Ke

Abstract excerpt

Background: Metabolic disorders are significant risk factors for peripheral neuropathy (PN) diseases. However, current clinical observational studies cannot fully determine the causal relationships between hypothyroidism (HT) and PN diseases. Methods: We performed univariate Mendelian randomization (MR) analyses using single nucleotide polymorphisms (SNPs) associated with hypothyroidism and two diseases...

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Diabetic Neuropathies
Genome-Wide Association Study
Hypothyroidism
Mendelian Randomization Analysis
Peripheral Nervous System Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39665022
DOI: 10.3389/fendo.2024.1436823
PMCID: PMC11631618

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