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Article

Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation.

Molecular biomedicine - 15 Jun 2026

Munteanu Serena, Wagih Gómez Jesús, Júdez Serrano Ángel, Saura Espín Daniel, Santos Mateo Juan José, Nicolás Rocamora María Elisa, Gil Ortuño Cristina, Bernabé García Ángel, Gimeno-Blanes Juan Ramon, Cayuela Fuentes María Luisa, Sabater Molina María

Abstract excerpt

Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical activity in disease onset, severity, and progression in DSP variant carriers remains unclear. This study aimed to generate a zebrafish model carrying a human DSP truncating variant to characterize homozygous dspb-/-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42295563
DOI: 10.1186/s43556-026-00476-7
PMCID: PMC13269591

Genes

DSP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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