Article
Uncovering Hereditary Tumor Syndromes: Emerging Role of Surgical Pathology.
Seminars in diagnostic pathology - 1 May 2018
Agaimy Abbas, Hartmann Arndt
Abstract excerpt
With the increased use of modern next generation sequencing technologies in routine molecular pathology practice, the proportion of cancer cases with a definite or probable hereditary background seems to be steadily increasing. Currently, it is assumed that ≥10% of all malignancies develop in the setting of germline predisposition. Diagnosis and recognition of cancer predisposition syndromes relies not rarely on...
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