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Article

Association of host metabolizing gene profiles with isoniazid and rifampicin resistance phenotypes among tuberculosis patients in Bangladesh.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2026

Uddin Mohammad Khaja Mafij, Mahmud Aar Rafi, Islam Ashabul, Ferdous Jannatul, Nasrin Rumana, Faruquee Hossain Md, Rahman S M Mazidur, Nanda Ranjan, Banu Sayera

Abstract excerpt

BACKGROUND: Genetic variation in host drug-metabolizing enzymes may influence the pharmacokinetics and treatment response of key anti-tuberculosis (TB) drugs, including isoniazid (INH) and rifampicin (RIF). This study investigated whether selected host metabolic gene profiles were associated with INH and RIF resistance phenotypes among TB patients. METHODS: This prospective study enrolled 41 bacteriologically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42289197
DOI: 10.1016/j.meegid.2026.105970

Genes

GSTT1
CYP1A2
GSTM1
CYP2E1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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