Article
The genomic profile of parathyroid carcinoma based on whole-genome sequencing.
International journal of cancer - 1 Nov 2020
Hu Ya, Zhang Xiang, Wang Ou, Bi Yalan, Xing Xiaoping, Cui Ming, Wang Mengyi, Tao Wei, Liao Quan, Zhao Yupei
Abstract excerpt
Parathyroid carcinoma (PC) is a rare endocrine malignancy with poor outcomes. Although some mutations such as CDC73 have been found in patients, the molecular mechanism of PC still needs extensive data to clarify. Whole-genome sequencing (WGS) was performed with frozen samples from 23 PC patients. Peripheral leukocytes were collected from 14 patients and served as controls. Somatic and germline gene alterations,...
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