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Article

Comprehensive genomic profiling and tumor mutational burden in parathyroid carcinoma: a nationwide real-world study from Japan.

Endocrine - 15 Jul 2026

Takano Yuko, Kikumori Toyone, Takeuchi Dai, Ichikawa Takahiro, Ando Yuichi

Abstract excerpt

PURPOSE: Parathyroid carcinoma (PC) is an extremely rare endocrine malignancy with limited treatment options for unresectable or recurrent cases. With the increasing use of comprehensive genomic profiling (CGP), treatment based on genomic findings is becoming more common. However, the frequency and clinical significance of elevated tumor mutational burden (TMB) in PC remain unclear because previous studies have...

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Source

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Identifiers

PMID: 42455276
DOI: 10.1007/s12020-026-04714-4
PMCID: PMC13373006

Genes

PC
CDC73
MEN1
TP53
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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