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Mutations M918T, M918L, and L1014F impair pyrethroid binding and alter gating of the Megalurothrips usitatus sodium channel.

Pest management science - 1 Oct 2026

Wang Likui, Gao Ruibo, Xia Guoliang, Yuan Linlin, Zhang Kun, Cao Peng, Li Fen, Wu Shaoying

Abstract excerpt

BACKGROUND: Mutations M918T/L and L1014F in the voltage-gated sodium channel (VGSC) are major causes of pyrethroid resistance in insects, but their functional effects in thrips remain unclear. We used Megalurothrips usitatus sodium channel (MuNav1-1) expression system to determine how these mutations affect channel gating and pyrethroid sensitivity. RESULTS: Electrophysiological analysis revealed that mutations...

Read the complete abstract on PubMed

Topics

Female
Animals
Xenopus laevis
Thysanoptera
Pyrethrins
Insecticide Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Amino Acid Sequence

NAV1.1 Voltage-Gated Sodium Channel

Insect Proteins

Molecular Docking Simulation

Insecticides

Source

Open in PubMed Open full text

Identifiers

PMID: 42286885
DOI: 10.1002/ps.71006
PMCID: PMC13569332

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