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Article

DNA-contact mutant p53 displaces BRCA2 from chromatin and drives R-loop-associated genome instability.

Genome biology - 11 Jun 2026

Li Fanfan, Fang Ke, Si Shuhan, Zhang Quanyong, Fan Menghan, Guo Chenghao, Sun Jie, Xie Zhuoying, Chen Kai, Chen Zhiyong, Ge Zheng, Lin Chengqi, Luo Zhuojuan

Abstract excerpt

BACKGROUND: Mutations in the tumor suppressor p53 are among the most frequent events in human cancers. Mutant p53 acquires oncogenic activities beyond the loss of tumor suppressive function. However, how different mutation subtypes differ in their contributions to tumorigenesis remains incompletely understood. RESULTS: Through pan-cancer TCGA analysis, we find that patients with p53 DNA contact mutations exhibit...

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Identifiers

PMID: 42277940
DOI: 10.1186/s13059-026-04151-6
PMCID: PMC13483591

Genes

BRCA2
DDX3X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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