Article
Global trends in metabolic-associated hepatocellular carcinoma: genetic and socio-demographic drivers.
Hepatology international - 1 Aug 2026
Wu Na, Xiong Xinying, Wang Xinyue, Wei Shuang, Shi Xinyu, Chen Yilin, Zhou Wenjun, Wang Jianying, Zhang Lei, Liu Baocheng, Song Hualing, Yu Huiting, Ji Guang
Abstract excerpt
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a primary driver of hepatocellular carcinoma (HCC). However, the synergistic impact of ancestral genetic susceptibility and socio-demographic transitions on the global MASLD-HCC landscape remains insufficiently quantified. METHODS: Using GBD 2021 data, we analyzed MASLD-HCC mortality and DALYs across 204 countries...
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