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Article

Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.

Gastroenterology - 1 Jan 2017

Broderick Peter, Dobbins Sara E, Chubb Daniel, Kinnersley Ben, Dunlop Malcolm G, Tomlinson Ian, Houlston Richard S

Abstract excerpt

High-throughput sequencing analysis has accelerated searches for genes associated with risk for colorectal cancer (CRC); germline mutations in NTHL1, RPS20, FANCM, FAN1, TP53, BUB1, BUB3, LRP6, and PTPN12 have been recently proposed to increase CRC risk. We attempted to validate the association between variants in these genes and development of CRC in a systematic review of 11 publications, using sequence data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27713038
DOI: 10.1053/j.gastro.2016.09.041
PMCID: PMC5860724

Genes

NTHL1
RPS20
BUB1
BUB3
FAN1
FANCM
LRP6
PTPN12

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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