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Article

Changes in the Transcriptome Caused by Mutations in the Ribosomal Protein uS10 Associated with a Predisposition to Colorectal Cancer.

International journal of molecular sciences - 31 May 2022

Tian Yueming, Babaylova Elena S, Gopanenko Alexander V, Tupikin Alexey E, Kabilov Marsel R, Malygin Alexey A, Karpova Galina G

Abstract excerpt

A number of mutations in the RPS20 gene encoding the ribosomal protein uS10 have been found to be associated with a predisposition to hereditary non-polyposis colorectal carcinoma (CRC). We transfected HEK293T cells with constructs carrying the uS10 minigene with mutations identical to those mentioned above and examined the effects of the produced proteins on the cellular transcriptome. We showed that uS10 with...

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PMID: 35682850
DOI: 10.3390/ijms23116174
PMCID: PMC9181716

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