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Article

Rational design for improved thermostability of methionine adenosyltransferase based on FoldX, Rosetta, and multidimensional virtual screening.

Food research international (Ottawa, Ont.) - 1 Sept 2026

Yang Yufei, Ma Huijun, Wang Dongpei, Jiang Ziyou, Wang Xinyue, Zhao Yujing, Li Ruiheng, Xu Chunming

Abstract excerpt

S-adenosyl-L-methionine (SAM) is a vital functional food ingredient and nutraceutical, but its industrial production is severely limited by the poor thermal stability of methionine adenosyltransferase (MAT). To overcome this bottleneck, this study presents a rational design strategy that integrates physical force fields with deep learning algorithms. Based on the crystal structure, molecular docking and B-factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42270249
DOI: 10.1016/j.foodres.2026.119535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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