Improvement and engineering of methionine γ-lyase from Pseudomonas deceptionensis based on molecular dynamics simulation and adaptive analysis for anti-tumor applications.

Abstract excerpt

Methionine γ-lyase (MGL) is a pyridoxal-5'-phosphate-dependent enzyme with strong potential as an anticancer therapeutic, yet its poor catalytic efficiency, low stability, and high immunogenicity limit clinical application. In this study, molecular dynamics (MD) simulations were employed to identify highly flexible regions of Pseudomonas deceptionensis MGL (PdMGL), revealing the C-terminal loop near the catalytic...

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