Article
AI-Assisted Multimodal Transcriptomic Analysis Identifies a Senescence-Related Prognostic Signature and Characterizes ADGRF5-Associated Malignant Phenotypes in Breast Cancer.
Cells - 1 Sept 2026
Liu Wenhao, Wu Wenhui, Chen Shubai, Chen Kaiqiong, Li Xin
Abstract excerpt
Cellular senescence (CS) is increasingly recognized as an important cell-state programme involved in breast cancer progression and therapeutic response, but its context-dependent molecular heterogeneity limits its application in prognostic assessment. In this study, GeneCompass-based all-gene in silico perturbation analysis was performed to identify candidate genes predicted to induce senescence or rejuvenation,...
Read the complete abstract on PubMedTopics
- Humans
- Breast Neoplasms
- Female
- Cellular Senescence
- Prognosis
- Phenotype
- Gene Expression Profiling