Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of CSE couples with BRAF V600E to fuel thyroid cancer metastatic progression through zinc-dependent activation of the EMT machinery.

Journal of experimental & clinical cancer research : CR - 10 Jun 2026

Xu Shichen, Yu Huixin, Wu Hongxun, Pan Zongfu, Xu Jiajie, Zhu Yun, Huang Botao, Cai Gangming, Gu Xiaobo, Yang Min, Pan Donghui, Pan Jie, Wu Jing, Cheng Xian, Bao Jiandong, Zhang Li

Abstract excerpt

BACKGROUND: BRAF V600E, the principal oncogenic driver in papillary thyroid carcinoma (PTC), strongly correlated with lymph node metastasis, yet the underlying molecular mechanisms remain elusive. METHODS: This study screened effector related to the BRAF V600E mutation and PTC progression through bioinformatics analysis. The precise functional roles and regulatory networks of cystathionine γ-lyase (CSE), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hydrogen Sulfide

Share to MicroRNAs

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42265770
DOI: 10.1186/s13046-026-03752-0
PMCID: PMC13474713

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of CSE couples with BRAF V600E to fuel thyroid cancer metastatic progression through zinc-dependent activation of the EMT machinery.PMID 42265770Read ↗

BRAF-activated ARSI suppressed EREG-mediated ferroptosis to promote BRAFV600E (mutant) papillary thyroid carcinoma progression and sorafenib resistance.Semantic proximity Read ↗

Targeting miR‐31 represses tumourigenesis and dedifferentiation of BRAF V600E ‐associated thyroid carcinomaSemantic proximity Read ↗

Bioinformatics analysis and experimental validation of Cystathionine-gamma-lyase as a potential biomarker for prognosis in hepatocellular carcinomaSemantic proximity Read ↗

METTL9 regulates N1-histidine methylation of zinc transporters to promote tumor growthSemantic proximity Read ↗

Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer.Semantic proximity Read ↗

SHMT2 promotes thyroid cancer metastasis through epigenetic activation of AKT signalingSemantic proximity Read ↗

BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and ProcessingSemantic proximity Read ↗

Fatty acid oxidation drives Acetyl-CoA-dependent H3K9ac reprogramming to promote adaptive resistance to BRAFV600E inhibition in thyroid cancerSemantic proximity Read ↗

Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma.Semantic proximity Read ↗

Regulation of cystathionine gamma-lyase/H₂S system and its pathological implication.Semantic proximity Read ↗

Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathwaySemantic proximity Read ↗

Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.