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Article

Causal effects of mental disorders on stroke subtypes: A proteome-wide Mendelian randomization and mediation analysis.

Medicine - 5 Jun 2026

Cong Linhao, Ji Hang, Yang Hailan, Kuang Guicheng, Liu Haitao, Sun Haogeng, Liu Yi

Abstract excerpt

Observational studies have demonstrated associations between mental disorders and stroke, yet causal relationships and potential molecular mechanisms remain elusive. To clarify this, we performed a bidirectional 2-sample Mendelian randomization (MR) analysis using genome-wide association studies summary statistics to assess the causal effects of 7 major mental disorders (schizophrenia, bipolar disorder, major...

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Identifiers

PMID: 42260810
DOI: 10.1097/MD.0000000000049108
PMCID: PMC13246131

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MMP12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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