Orange Peel Powder Improves Constipation-Related Phenotypes and Is Associated with Coordinated Colonic and Brain-Related Changes in a Doxorubicin- and Loperamide-Treated Rat Model.

Abstract excerpt

OBJECTIVES: This study aimed to determine whether orange peel powder (OP) improves constipation-related phenotypes in a doxorubicin- and loperamide-treated rat model and whether such improvement is accompanied by coordinated histological and molecular changes in colon and brain tissues. METHODS: Forty-eight 12-wk-old male Sprague-Dawley rats were randomly assigned to 6 groups (n = 8/group): blank control (BC),...

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