Optimizing treatment selection and timing of allogeneic haematopoietic stem cell transplantation in acute myeloid leukaemia with concurrent feline McDonough sarcoma (FMS)-like tyrosine kinase 3 internal tandem duplication, nucleophosmin 1 and deoxyribonucleic acid (DNA) methyltransferase 3 alpha mutations.

doi:10.1111/bjh.70593

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Optimizing treatment selection and timing of allogeneic haematopoietic stem cell transplantation in acute myeloid leukaemia with concurrent feline McDonough sarcoma (FMS)-like tyrosine kinase 3 internal tandem duplication, nucleophosmin 1 and deoxyribonucleic acid (DNA) methyltransferase 3 alpha mutations.

British journal of haematology - 1 Aug 2026

Li Ruixin, Yao Yiyi, Yang Donglin, Mao Liping, Lou Yinjun, He Yi, Meng Haitao, Yu Wenjuan, Pang Aiming, Feng Sizhou, Tong Hongyan, Han Mingzhe, Jin Jie, Tang Meiwen, Jiang Erlie, Wang Huafeng

Abstract excerpt

Acute myeloid leukaemia (AML) patients with concurrent FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD), nucleophosmin 1 (NPM1) and DNA methyltransferase 3 alpha (DNMT3A) mutations exhibit heterogeneous treatment outcomes. To identify optimal strategies for this subset, we retrospectively analysed 2541 AML patients with next-generation sequencing from 2016 to 2023. Among them, 113 harboured...

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Identifiers

PMID: 42230972
DOI: 10.1111/bjh.70593
PMCID: PMC13462167

Genes

DNMT3A
FLT3
NPM1

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Optimizing treatment selection and timing of allogeneic haematopoietic stem cell transplantation in acute myeloid leukaemia with concurrent feline McDonough sarcoma (FMS)-like tyrosine kinase 3 internal tandem duplication, nucleophosmin 1 and deoxyribonucleic acid (DNA) methyltransferase 3 alpha mutations.PMID 42230972Read ↗

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