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Article

Defects in energy metabolism increase the susceptibility of Staphylococcus aureus and its small colony variants (SCVs) to Staphylococcus lugdunensis and lugdunin.

Microbiology spectrum - 7 Oct 2025

Liu Chao-Chin, Chang Shih-Cheng, Shu Jwu-Ching, Lin Mei-Hui

Abstract excerpt

Lugdunin, produced by Staphylococcus lugdunensis, exhibits potent antimicrobial activity against a broad range of Gram-positive bacteria, including Staphylococcus aureus. This study aims to elucidate the mechanisms underlying the susceptibility of S. aureus to lugdunin by screening a transposon-based mutant library generated using the lugdunin-susceptible S. aureus strain HG001. We identified four S. aureus...

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Topics

Staphylococcus lugdunensis
Energy Metabolism
Staphylococcus aureus
Anti-Bacterial Agents
Microbial Sensitivity Tests
Staphylococcal Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Bacterial Proteins

Mutation

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Identifiers

PMID: 40844229
DOI: 10.1128/spectrum.01006-25
PMCID: PMC12502701

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