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Article

Understanding how depression genetic liability shapes executive function: Epidemiological evidence for symptom-mediated pathways.

Journal of affective disorders - 15 Oct 2026

Camerini Laísa, Carpena Marina Xavier, Santana Victor F, Santos Iná S, Munhoz Tiago N, Genro Júlia Pasqualini, Oliveira Isabel O, Matijasevich Alicia, Tovo-Rodrigues Luciana

Abstract excerpt

Executive function (EF) impairments are common in depression (MD), yet the developmental pathways linking MD genetic liability to cognitive outcomes remain unclear. In this study, we examined whether genetic liability to MD is associated with EF performance at ages 11 and 15 in a Brazilian population-based birth cohort and assessed whether MD symptoms in adolescents and their mothers mediate these associations....

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Brazil
Depression
Executive Function
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Memory, Short-Term

Multifactorial Inheritance

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PMID: 42217641
DOI: 10.1016/j.jad.2026.122059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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