The effect of prenatal maternal stress on adolescent internalizing symptoms and the genetic moderation of executive functioning and prefrontal cortex.

doi:10.1017/S0033291726105431

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Article

The effect of prenatal maternal stress on adolescent internalizing symptoms and the genetic moderation of executive functioning and prefrontal cortex.

Psychological medicine - 9 Sept 2026

Kraft Brage, MacSweeney Niamh, Page Christian M, Lyle Robert, Tsotsi Stella, Ulset Vidar, Chen Chi-Hua, Tamnes Christian K, Czajkowski Nikolai, Dissen Ingrid Anna Ørstavik, Wang Yunpeng, Bekkhus Mona

Abstract excerpt

BACKGROUND: Prenatal maternal stress is a known risk factor for later emotional problems, yet not all exposed offspring develop psychopathology. Executive functioning and prefrontal cortex structure and activity may buffer these effects, but it remains unclear whether genetic predispositions in these domains moderate associations with adolescent internalizing symptoms. METHODS: We examined 3,111 adolescents...

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Topics

Humans
Female
Prefrontal Cortex
Executive Function
Adolescent

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prenatal Exposure Delayed Effects

Pregnancy

Stress, Psychological

Male

Genetic Risk Score

Genetic Predisposition to Disease

Magnetic Resonance Imaging

Gene-Environment Interaction

Source

Open in PubMed

Identifiers

PMID: 42711782
DOI: 10.1017/S0033291726105431

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