ADH1B-ALDH2 genotype combinations, age-related risk, and field cancerization in head and neck and upper GI cancer screening in 10 073 alcohol-dependent men.

doi:10.1093/carcin/bgag034

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ADH1B-ALDH2 genotype combinations, age-related risk, and field cancerization in head and neck and upper GI cancer screening in 10 073 alcohol-dependent men.

Carcinogenesis - 7 Jul 2026

Yokoyama Akira, Omori Tai, Yokoyama Tetsuji

Abstract excerpt

We analyzed initial endoscopic screening results, including esophageal iodine staining and oropharyngolaryngeal inspection, from 10 073 Japanese alcohol-dependent men (30-79 years) between 1993 and 2025. After adjustment for age, drinking and smoking habits, and screening year, using ADH1B*2 (rs1229984) plus ALDH2*1/*1 as the reference, the cancer risk (odds ratio (OR) [95% confidence interval (CI)]) associated...

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Identifiers

PMID: 42217254
DOI: 10.1093/carcin/bgag034

Genes

ALDH2
ADH1B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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