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Article

Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men.

International journal of cancer - 15 Jun 2012

Yokoyama Akira, Hirota Teruyuki, Omori Tai, Yokoyama Tetsuji, Kawakubo Hirofumi, Matsui Toshifumi, Mizukami Takeshi, Mori Shuka, Sugiura Hitoshi, Maruyama Katsuya

Abstract excerpt

We investigated the development of esophageal neoplasia in biopsy specimens of the distinct iodine-unstained lesions (DIULs) ≥ 5 mm detected in 280 of 2,115 Japanese alcoholic men who underwent screening by esophageal iodine staining. Low-grade intraepithelial neoplasia (LGIN) was diagnosed in 155 of them, high-grade intraepithelial neoplasia (HGIN) in 57, and invasive SCC in 35. The size of the DIULs increased...

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Source

Identifiers

PMID: 21796615
DOI: 10.1002/ijc.26296

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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