Article
Large-scale analysis of temporal gene expression variation in peripheral blood.
Nature communications - 29 May 2026
Mishra Neha, Kimmig Franziska, Vandeputte Doris, Talevi Valentina, De Commer Lindsey, Verspecht Chloe, Vich Vila Arnau, El-Sayed Moustafa Julia S, Kreft Lukasz, Botzki Alexander, El Darzi Youssef, Proost Sebastian, Devolder Lindsay, Wang Dongmeng, Bernardes Joana P, Aziz N Ahmad, Franke Andre, Schreiber Stefan, Dermitzakis Emmanouil T, Vieira-Silva Sara, Falony Gwen, Small Kerrin S, Breteler Monique M B, Schultze Joachim L, Raes Jeroen, Rosenstiel Philip
Abstract excerpt
Transcriptomic profiling of peripheral blood offers a promising, non-invasive approach for disease diagnosis and monitoring. However, its clinical translation is hindered by limited knowledge of the natural temporal variation. Here, we present a comprehensive reference map of longitudinal transcriptomic variability, based on RNA-sequencing of 333 healthy individuals sampled at three time points over six months....
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