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Widespread seasonal gene expression reveals annual differences in human immunity and physiology

12 May 2015

Abstract excerpt

Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood...

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PMID: 25965853
DOI: 10.1038/ncomms8000

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