Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rosiglitazone alleviates Parkinson's disease phenotypes of Drosophila via dCTP-mediated inhibition of AGE-RAGE pathway.

Neuropharmacology - 1 Oct 2026

Kang Yubing, Yang Yan, Wang Zumeng, Chang Yumin, Wang Ning, Yang Jing, Lim Kahleong, Yu Fengwei, Wang Mingyu, Lu Li, Zhang Chengwu

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is an aging-related neurodegenerative disorder, which threatens the health and life of millions of patients worldwide, but remains incurable. Developing novel interventive strategy is urgent yet unmet. In recent years, it was well accepted that pathogenesis of PD closely correlated with aberrant glucolipid metabolism. The antidiabetic drug, Rosiglitazone (Rosi), one typical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Mitochondria

Share to Parkinson Disease

Share to Receptor for Advanced Glycation End Products

Share to Rosiglitazone

Share to Signal Transduction

Source

Identifiers

PMID: 42214454
DOI: 10.1016/j.neuropharm.2026.111047

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rosiglitazone alleviates Parkinson's disease phenotypes of Drosophila via dCTP-mediated inhibition of AGE-RAGE pathway.PMID 42214454Read ↗

Neuroprotective potential of an <i>Ayurvedic</i> compound “Ras-Sindoor” on <i>Drosophila melanogaster</i> model of Parkinson’s diseaseSemantic proximity Read ↗

Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s diseaseSemantic proximity Read ↗

Age specific neuroprotection of curcumin is through differential modulation of brain dopamine metabolism: Insights from Drosophila model of Parkinson’s diseaseSemantic proximity Read ↗

Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans modelsSemantic proximity Read ↗

Ameliorative Role of Nutraceuticals on Neurodegenerative Diseases Using theDrosophila melanogasteras a Discovery Model to Define BioefficacySemantic proximity Read ↗

Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF‐16/FOXO‐ and SKN‐1/NRF2‐Related Signaling PathwaysSemantic proximity Read ↗

Adult health and transition stage-specific rotenone-mediated Drosophila model of Parkinson’s disease: Impact on late-onset neurodegenerative disease modelsSemantic proximity Read ↗

Glial Nrf2 signaling mediates the neuroprotection exerted by <i>Gastrodia elata</i> Blume in Lrrk2-G2019S Parkinson’s diseaseSemantic proximity Read ↗

The alleviative effect of Calendula officinalis L. extract against Parkinson’s disease-like pathology in zebrafish via the involvement of autophagy activationSemantic proximity Read ↗

Folic Acid Supplementation Ameliorates Oxidative Stress, Metabolic Functions and Developmental Anomalies in a Novel Fly Model of Parkinson’s DiseaseSemantic proximity Read ↗

Epicoccin A Ameliorates PD-Like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative StressSemantic proximity Read ↗

Identification of structural features of selected flavonoids responsible for neuroprotection using a <i>Drosophila</i> model of Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.