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Article

Global epidemiology of Helicobacter pylori iceA genotypes: heterogeneity and virulence implications.

Microbiology spectrum - 7 Jul 2026

Ren Yayi, Xie Jia, Zhou Long, Zhang Zelin, Xia Tingting, Ning Jie, Wu Chao

Abstract excerpt

The contact-induced epithelium gene A (iceA), with allelic variants iceA1 and iceA2, remains a controversial virulence factor in Helicobacter pylori due to inconsistent clinical outcomes. In this study, we analyzed 1,427 H. pylori genomes from the NCBI database and 200 clinical isolates from Shenzhen, China, to elucidate the global distribution of iceA genotypes and their associations with other virulence...

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Identifiers

PMID: 42214367
DOI: 10.1128/spectrum.02024-25
PMCID: PMC13340068

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