Article
Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori.
Gene - 4 Apr 2000
Figueiredo C, Quint W G, Sanna R, Sablon E, Donahue J P, Xu Q, Miller G G, Peek R M, Blaser M J, van Doorn L J
Abstract excerpt
The genetic organization and sequence heterogeneity of the iceA locus of Helicobacter pylori was studied, and the existence of two distinct gene families, iceA1 and iceA2, at this locus was confirmed. iceA1 has significant sequence homology to nlaIIIR, encoding an endonuclease in Neisseria lactamica, but the similarity at the protein level is limited, due to frameshift mutations of iceA1 in most H. pylori...
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