Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome Plasticity in Cultured Leishmania donovani: Comparison of Early and Late Passages

3 Jul 2018

Abstract excerpt

Leishmania donovani possesses a complex heteroxenic life cycle where infective metacyclic promastigotes are pre-adapted to infect their host and cope up with intracellular stress. Exploiting the similarities between cultured and sandfly derived promastigotes, we used early and late passage cultured promastigotes to show specific changes at genome level which compromise pathogen fitness reflected in gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insect Resistance and Genetics
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30018594
DOI: 10.3389/fmicb.2018.01279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome Plasticity in Cultured Leishmania donovani: Comparison of Early and Late PassagesPMID 30018594Read ↗

Genomic insights into virulence mechanisms of Leishmania donovani: evidence from an atypical strain.Semantic proximity Read ↗

Integrative genomic, proteomic and phenotypic studies of Leishmania donovani strains revealed genetic features associated with virulence and antimony-resistance.Semantic proximity Read ↗

A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulenceSemantic proximity Read ↗

Leishmania major virulence attenuation in vitro: An old conundrum revisited in the omics era.Semantic proximity Read ↗

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric AmplificationSemantic proximity Read ↗

Genome wide comparison of Leishmania donovani strains from Indian visceral leishmaniasis and para-kala-azar dermal leishmaniasis patientsSemantic proximity Read ↗

Leishmania: conserved evolution--diverse diseases.Semantic proximity Read ↗

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferationSemantic proximity Read ↗

Comparative and systems analyses of Leishmania spp. non-coding RNAs through developmental stagesSemantic proximity Read ↗

Gene Annotation and Transcriptome Delineation on a De Novo Genome Assembly for the Reference Leishmania major Friedlin StrainSemantic proximity Read ↗

SOLiD™ Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key QuestionsSemantic proximity Read ↗

Gene deletion as a possible strategy adopted by New World <i>Leishmania infantum</i> to maximize geographic dispersionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.