Article

The UFMylation pathway is impaired in Alzheimer’s disease

2024-05-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Alzheimer’s disease (AD) is characterized by the presence of neurofibrillary tangles made of hyperphosphorylated tau and senile plaques composed of beta-amyloid. These pathognomonic deposits have been implicated in the pathogenesis, although the molecular mechanisms and consequences remain undetermined. UFM1 is an important, but understudied ubiquitin-like protein that is co...

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Literature Corpus work: f2298ff4-4429-506b-bb16-971d3cb2aaad
DOI: 10.1101/2024.05.24.595755

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