Familial high-risk (FHR) for severe mental illness in clinical high-risk for psychosis (CHR-P): a systematic review and meta-analysis.

doi:10.1007/s00406-026-02267-1

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Article

Familial high-risk (FHR) for severe mental illness in clinical high-risk for psychosis (CHR-P): a systematic review and meta-analysis.

European archives of psychiatry and clinical neuroscience - 1 Sept 2026

Raballo Andrea, Poletti Michele, Preti Antonio

Abstract excerpt

Preventive interventions for young help-seekers at clinical high risk for psychosis (CHR-P) critically depend on the progressive improvement of risk stratification. However, there is evidence that the transparent reporting of relevant variables plausibly affecting longitudinal outcomes (e.g. pre-assessment pharmacological exposure) remains suboptimal. In this study we focused on familial high-risk (FHR) for...

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PMID: 42207289
DOI: 10.1007/s00406-026-02267-1

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