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[Hereditary breast cancer : Syndromes, pathology, clinical aspects].

Pathologie (Heidelberg, Germany) - 1 Sept 2026

Lebeau Annette, Schmutzler Rita

Abstract excerpt

Approximately 5-10% of all breast cancers arise from a hereditary predisposition. In addition to the high-risk genes BRCA1 and BRCA2, other genes involved in homologous recombination repair (including PALB2, ATM, CHEK2, RAD51C/D, BARD1) and genes associated with classic tumor predisposition syndromes (TP53, PTEN, STK11, CDH1, NF1) are associated with an increased risk of breast cancer. In addition, polygenic risk...

Topics

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Breast Neoplasms
BARD1 gene
NF1 gene
PALB2 gene
STK11 gene
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Neoplastic Syndromes, Hereditary

Source

Identifiers

PMID: 42201356
DOI: 10.1007/s00292-026-01570-x

Genes

BRCA1
CDH1
ATM
BARD1
BRCA2
CHEK2
NF1
PALB2
PTEN
RAD51C
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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