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Article

The hidden threats posed by Japanese encephalitis virus genotype V.

Journal of virology - 25 Nov 2025

Li Qi, Mishra Hridesh, Kain Kevin C, Wang Ran

Abstract excerpt

Japanese encephalitis virus (JEV) remains a major cause of viral encephalitis in Asia. Among its five genotypes (GI-GV), genotype V (GV) has re-emerged and become the predominant lineage in mosquitoes in the Republic of Korea, with sporadic human cases also reported. GV JEV displays differences from other genotypes in genomic sequence, antigenicity, and pathogenicity, and animal studies indicate higher lethality....

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PMID: 41186391
DOI: 10.1128/jvi.01644-25
PMCID: PMC12646001

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