Article
Association of chronic wasting disease susceptibility with prion protein variation in white-tailed deer (Odocoileus virginianus).
Prion - 1 Dec 2020
Ishida Yasuko, Tian Ting, Brandt Adam L, Kelly Amy C, Shelton Paul, Roca Alfred L, Novakofski Jan, Mateus-Pinilla Nohra E
Abstract excerpt
Chronic wasting disease (CWD) is caused by prions, infectious proteinaceous particles, PrPCWD. We sequenced the PRNP gene of 2,899 white-tailed deer (WTD) from Illinois and southern Wisconsin, finding 38 haplotypes. Haplotypes A, B, D, E, G and 9 others encoded Q95G96S100N103A123Q226, designated 'PrP variant A.' Haplotype C and 4 other haplotypes encoded PrP 'variant C' (Q95S96S100N103A123Q226). Haplotype F and...
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