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Article

CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers.

Cell reports. Medicine - 16 Jun 2026

Ding Chaodong, Wang Xiaqing, Yuan Yiting, Zhang Yuefang, Hu Yixin, Wang Changhe, Du Ailian, Qiu Zilong

Abstract excerpt

Variants in CSNK2B cause neurodevelopmental disorders with autism and epilepsy, but therapeutic evidence and translatable biomarkers remain limited. We generate Csnk2b haploinsufficient mice that recapitulate key disease features, including social and cognitive deficits, anxiety-like behavior, spontaneous seizures, cortical abnormalities, and reduced inhibitory interneurons. Early postnatal, brain-wide gene...

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Source

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Identifiers

PMID: 42190665
DOI: 10.1016/j.xcrm.2026.102832
PMCID: PMC13293933

Genes

CSNK2B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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