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Functional precision oncology platform of BRAFV600E-mutated colorectal cancer organoids predicts therapy response and reveals RNF43-mediated immunogenicity.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jul 2026

Mo Shaobo, Luo Wenqin, Yang Jiajun, He Xingfeng, Ma Maoguang, Cai Xin, Li Yaqi, Hu Xiang, Mu Peiyuan, Cai Sanjun, Ma Xiaoji, Liu Fangqi, He Xigan, Zou Hai, Peng Junjie

Abstract excerpt

BACKGROUND: BRAFV600E-mutant colorectal cancer (CRC) represents an aggressive molecular subtype characterized by poor prognosis and resistance to standard therapies. Predictive models to guide treatment selection and overcome drug resistance are urgently needed. METHODS: We established a biobank of patient-derived organoids (PDOs) and matched xenografts (PDOXs) from BRAFV600E-mutant CRC, capturing inter- and...

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PMID: 42190325
DOI: 10.1016/j.drup.2026.101414

Genes

RNF43
BRAF
EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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