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Article

Association between tumor genomic mutations and the risk of PD-1 inhibitor-induced hypophysitis: a retrospective cohort study.

Frontiers in endocrinology - 1 Jan 2026

Zheng Yuanyuan, Chen Yizhen, Lin Wei, Min Le

Abstract excerpt

Background: Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with hypophysitis being a serious endocrine toxicity that often requires hormone replacement and poses a risk of adrenal crisis. Biomarkers for predicting ICI-induced hypophysitis are lacking. Methods: This retrospective, single-center cohort study used the Research Patient Data Registry (RPDR) to identify adults with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42339089
DOI: 10.3389/fendo.2026.1845186
PMCID: PMC13283881

Genes

BABAM1
CDH4
KDM5C
PAXIP1
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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