Article
Pathogenesis of renal involvement in primary Sjögren's disease: convergence of multifactorial mechanisms on immune dysregulation.
Frontiers in immunology - 1 Jan 2026
Yang Jingya, Cui Yingchun, Bai Xiaoying, Guo Qiaoyan, Cui Wenpeng, Xu Feng
Abstract excerpt
Primary Sjögren's disease (pSjD) is a chronic systemic autoimmune disease in which immune-mediated pathology is not confined to exocrine glands but also affects multiple organ systems. Renal involvement constitutes a clinically meaningful manifestation of pSjD and may exert a considerable impact on disease progression, prognosis, and treatment selection. However, the pathogenic basis of renal injury in pSjD is...
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