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Article

The pathological Huntingtin CAG triplet expansion differentially affects the diagnosis of systemic and organ-specific autoimmune diseases.

Frontiers in immunology - 1 Jan 2026

Heyd Moritz, Landwehrmeyer G Bernhard, Lewerenz Jan

Abstract excerpt

Background: In Huntington's disease (HD), signs of inflammatory activation are found in the brain, cerebrospinal fluid, and blood. HD monocytes are reported to be hyperreactive in vitro. Thus, HD mutation might affect the immune system. Aim: To explore the frequency of autoimmune diseases (AIDs) in HD mutation carriers (people with the HD mutation, PwHD) compared to control participants (CPs) as markers of immune...

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Identifiers

PMID: 42183198
DOI: 10.3389/fimmu.2026.1689962
PMCID: PMC13194399

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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