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Article

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

30 Nov 2018

Abstract excerpt

Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to patients with systemic sclerosis, Alzheimer's disease, and ovarian cancer. Sex, age and pathological...

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PMID: 30523250
DOI: 10.1038/s41467-018-07598-9

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