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Article

Aberrant activation of renal functional reserve and reduced tubule flow, but not obstruction, is associated with cystogenesis in Pkd2 mutant kidneys.

Function (Oxford, England) - 1 Jun 2026

Thomas Isis N, Rajendran Sneha, Li Zhang, Haycraft Courtney J, Croyle Mandy J, Yoder Bradley K

Abstract excerpt

Disruption of PKD2 function causes polycystic kidney disease (PKD) and leads to the formation of cysts in the kidney in both mice and humans. PKD is progressive, initiating with the formation of tubule dilations that expand into large cysts, causing the destruction of renal parenchyma and loss of kidney function. The mechanisms initiating tubule dilation and expansion are uncertain. Tubule obstruction has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42176282
DOI: 10.1152/function.114.2025
PMCID: PMC13307687

Genes

PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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