Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation.

eLife - 22 May 2026

Aguilar Gustavo, Sickmann Michèle E, Bieli Dimitri, Born Gordian, Affolter Markus, Müller Martin

Abstract excerpt

The establishment of tissue axes is fundamental during embryonic development. In the Drosophila wing, the anterior/posterior (AP) and the dorsal/ventral (DV) compartment boundaries provide the basic coordinates around which the tissue develops. These boundaries arise as a result of two lineage decisions, the acquisition of posterior fate by the selector gene engrailed (en) and dorsal fate by the selector gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Drosophila

Share to Enhancer Elements, Genetic

Share to Homeodomain Proteins

Share to LIM-Homeodomain Proteins

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 42172144
DOI: 10.7554/eLife.91713
PMCID: PMC13197166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation.PMID 42172144Read ↗

The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer.Semantic proximity Read ↗

A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing.Semantic proximity Read ↗

Drosophila wing development in the absence of dorsal identity.Semantic proximity Read ↗

A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing.Semantic proximity Read ↗

Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila.Semantic proximity Read ↗

Specification of the wing by localized expression of wingless protein.Semantic proximity Read ↗

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.Semantic proximity Read ↗

Enhancer blocking and transvection at the Drosophila apterous locus.Semantic proximity Read ↗

Cis-regulation in the Drosophila Bithorax Complex.Semantic proximity Read ↗

Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc.Semantic proximity Read ↗

<i>apterous A</i> specifies dorsal wing patterns and sexual traits in butterfliesSemantic proximity Read ↗

Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.