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Article

Exploration of deleterious single nucleotide polymorphisms in late-onset Alzheimer disease susceptibility genes.

Gene - 10 Jan 2013

Masoodi Tariq Ahmad, Al Shammari Sulaiman A, Al-Muammar May N, Alhamdan Adel A, Talluri Venkateswar Rao

Abstract excerpt

Non-synonymous single nucleotide polymorphisms (nsSNPs) are considered as biomarkers to disease susceptibility. In the present study, nsSNPs in CLU, PICALM and BIN1 genes were screened for their functional impact on concerned proteins and their plausible role in Alzheimer disease (AD) susceptibility. Initially, SNPs were retrieved from dbSNP database, followed by identification of potentially deleterious nsSNPs...

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Source

Identifiers

PMID: 22960267
DOI: 10.1016/j.gene.2012.08.026

Genes

BIN1
PICALM
CLU

Variants

rs12800974
rs12800974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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