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Article

AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.

Cancer letters - 10 Jul 2023

Xu Ye, Zhang Xuefeng, Zhang Ruitian, Sun Yuening, Liu Jian, Luo Chengju, Yang Junyi, Fang Weiming, Guo Qinglong, Wei Libin

Abstract excerpt

HCC remains one of the most prevalent and deadliest cancers. Serum AFP level is a biomarker for clinical diagnosis of HCC, instead the contribution of AFP to HCC development is clearly highly complex. Here, we discussed the effect of AFP deletion in the tumorigenesis and progression of HCC. AFP deletion in HepG2 cells inhibited the cell proliferation by inactivating PI3K/AKT signaling. Surprisingly, AFP KO HepG2...

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Identifiers

PMID: 37217071
DOI: 10.1016/j.canlet.2023.216240

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