The impact of breast cancer polygenic risk score disclosure on decisional conflict around risk-reducing mastectomy in women with pathogenic BRCA1/2 variants.

doi:10.1016/j.gim.2026.102609

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The impact of breast cancer polygenic risk score disclosure on decisional conflict around risk-reducing mastectomy in women with pathogenic BRCA1/2 variants.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2026

Ongaro Giulia, Salafia Caroline, Sheikh Rania, Schofield Elizabeth, Clark Dana Farengo, Ebrahimzadeh Jessica, Chittenden Anu, Stopfer Jill E, Brower Jamie, Symecko Heather, Ovadia Hannah, Husband Alexander, Barr Hadley, Mukherjee Semanti, Hay Jennifer L, Stadler Zsofia K, Offit Kenneth, Garber Judy E, Domchek Susan M, Robson Mark E, Hamilton Jada G

Abstract excerpt

PURPOSE: Women with BRCA1/2 pathogenic variants (PVs) face high breast cancer risks and complex preventive decisions, including whether to undergo risk-reducing mastectomy, which can generate decisional conflict. Polygenic risk scores (PRSs) offer individualized risk estimates that may support informed preventive decisions. We examined whether PRS disclosure reduces decisional conflict about risk-reducing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to Decision Making

Share to Genetic Risk Score

Share to Genetic Testing

Share to Mastectomy

Share to Prophylactic Mastectomy

Source

Open in PubMed Open full text

Identifiers

PMID: 42165229
DOI: 10.1016/j.gim.2026.102609
PMCID: PMC13322037

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of breast cancer polygenic risk score disclosure on decisional conflict around risk-reducing mastectomy in women with pathogenic BRCA1/2 variants.PMID 42165229Read ↗

Breast cancer polygenic risk scores: A 12-month prospective study of patient reported outcomes and risk management behaviorSemantic proximity Read ↗

Psychological distress and decision-making factors for prophylactic bilateral mastectomy in cancer-unaffected BRCA1/2 pathogenic variant carriers.Semantic proximity Read ↗

Women’s Responses and Understanding of Polygenic Breast Cancer Risk InformationSemantic proximity Read ↗

Variants of uncertain significance in BRCA testing: evaluation of surgical decisions, risk perception, and cancer distress.Semantic proximity Read ↗

Effects of false-positive cancer screenings and cancer worry on risk-reducing surgery among BRCA1/2 carriers.Semantic proximity Read ↗

Psychological and emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&ISemantic proximity Read ↗

A Mixed-Methods Exploration of Stakeholder Experiences and Perspectives on Integrating Polygenic Breast Cancer Risk Scores into Swedish Clinical PracticeSemantic proximity Read ↗

Decisional regret following risk-reducing mastectomy versus surveillance among Japanese women with breast cancer carrying BRCA1/2 pathogenic variantsSemantic proximity Read ↗

Patient-Reported Outcome Measures may optimize shared decision-making for cancer risk management in BRCA mutation carriers.Semantic proximity Read ↗

Factors influencing decision regret regarding contralateral prophylactic mastectomy in women at high risk of hereditary breast cancer: a cross-sectional study.Semantic proximity Read ↗

Optimizing shared decision-making for risk-reducing mastectomy in women with Li–Fraumeni syndrome using patient-reported outcome measuresSemantic proximity Read ↗

BRCA1/2 test results impact risk management attitudes, intentions, and uptake.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.