The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial.

doi:10.1158/1940-6207.CAPR-26-0044

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Article

The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2026

Senter Leigha, Hovick Shelly, Notestine Rachel, Norden Lauren, Benny Nadia, Phillips Shannon, Willoughby Ava, Pyatt Robert, Agnese Doreen, Mak Julie S, DePersia Allison, Colonna Sarah V, Maxwell Whitney F, Kohlmann Wendy, Spaeth Erika L, Gordon Ora, Thull Darcy, Brock Guy N, Webb Amy, Smith Rachel M, Toland Amanda Ewart

Abstract excerpt

Individuals with germline BRCA1 or BRCA2 pathogenic variants (PV) may struggle with risk management decision-making. Advancements in technology could provide more specific risk information to patients, but the impact of this information is unknown. The Clinical Application of Refined Risk Estimates Study is a two-arm randomized controlled trial in women with a BRCA1/BRCA2 PV. The primary objective was to...

Read the complete abstract on PubMed

Topics

Humans
Female
Adult
Middle Aged
BRCA2 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

BRCA1 Protein

Risk Assessment

Genetic Predisposition to Disease

Germ-Line Mutation

Decision Making

Follow-Up Studies

Breast Neoplasms

Heterozygote

Ovarian Neoplasms

Genetic Testing

Return of Individual Research Results

Source

Open in PubMed Open full text

Identifiers

PMID: 42339534
DOI: 10.1158/1940-6207.CAPR-26-0044
PMCID: PMC13389799

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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